Objective This study explored the application effects of a self-designed atomizer fixing bracket in the atomization process of patients. Methods The self-designed atomizer fixing bracket includes 4 parts with a base,a connecting pipe,a universal hose and a fixing part of the atomizer cup. 63 patients in the emergency ward of a tertiary first-class hospital in Hefei from January to June 2020 were selected as the control group;63 patients from July to December 2020 were in the test group. Patients of the test group used a self-designed atomizer fixing bracket to assist atomization process,while patients of the control group used conventional standard atomization methods for atomization treatment. The comfort of atomization,the atomization time and the number of atomization interruptions were observed in 2 groups. Results The atomization time of the test group were（23.05±2.86） min,and the atomization time of the control group were（16.46±2.31） min with statistically significant differences between the 2 groups（P<0.001）. The numbers of atomization interruptions in the test group were（0.86±0.47） times,while the numbers of atomization interruptions in the control group were（1.77±0.57） times,and the difference between the 2 groups was statistically significant（P=0.013）. The comfort rate of atomization in the test group was 92.06%,and the control group was 76.19%. The difference between the 2 groups was statistically significant（P=0.031）. Conclusion The atomizer fixing bracket was convenient to use,which can help to improve the comfort of atomization of patients,reduce the number of interruptions of atomization,extend the time of atomization,and help improving the compliance of patients with atomization therapy.